Research References

The articles on this site, mostly written by PhysiVāntage founder Eric Hörst, draw heavily on the incredible work of researchers on five continents. Following are a list of researchers and papers seminal to the creation of Supercharged Collagen.

Baar, K. Minimizing injury and maximizing return to play: Lessons from engineered ligaments. Sports Medicine 2017 Mar; 47:S5-S11.

Bohm, S., Human tendon adaptation in response to mechanical loading: A systematic review and meta-analysis of exercise intervention studies on healthy adults. Sports Medicine – Open 2015; 1:7.

Clark, K.L., et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr. Med.Res. 2008; Opin.24: 1485–1496

Cook, J., Rio, E., Purdam, C., et al. Revisiting the continuum model of tendon pathology: What is its merit in clinical practice and research? British Journal of Sports Medicine 2016; 50: 1187-1191.

De Paz-Lugo, P., et al. High glycine concentration increases collagen synthesis by articular chondrocytes—Acute glycine deficiency could be an important case of osteoarthritis. Amino Acids. 2018; 50(10): 1357-1365. 

Fenwick, S., et al. The vasculature and its role in the damaged and healing tendon. Arthritis Res, 2002: 4:252-260.

Gronemann, S., et al. Collagen and muscle pathology in fibromyalgia patients. Rheumatology 2004; 1:27-31.

Jones, G., Schöffl, V., Johnson, M. Incidence diagnoses, and management of injury in sport climbing and bouldering: A Critical Review. Current Sports Medicine Reports 2018; 17(11): 396-401.

Kjaer, M., Magnusson, P., et al. Extracellular matrix adaptation of tendon and skeletal muscle to exercise. J. Anatomy. 2006; 208: 445-450.

Magnusson, P., Langberg, H., Kjaer, M. The pathogenesis of tendinopathy: Balancing the response to loading. Nature Reviews Rheumatology 2010; 6:262-268.

Paxton, J.Z., et al. Optimizing an intermittent stretch paradigm using ERK1/2 phosphorylation results in increased collagen synthesis in engineered ligaments. Tissue Eng Part A. 2012 Feb;18(3-4):277-284.

Praet, S., Purdam, C., et al. Oral supplementation of specific collagen peptides combined with calf-strengthening exercises enhances function and reduces pain in Achilles tendinopathy patients. Nutrients 2019; 11,76.

Proksch, E. et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacological Physiol. 2014; 27(1):47-55

Ramaswamy, K.S., et al. Lateral transmission of force is impaired in skeletal muscles of dystrophic mice and very old rats. J. Physiol. 2011; 589:1195-1208.

Shaw, G. et al. Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. American Journal of Clinical Nutrition 2016; 105(1).

Shaw, G., et al. Vitamin C-enriched gelatin supplementation prior to intermittent exercises: Strategies to enhance anabolism: Nutr. Metab. 2017; 105:136-43.

Sibilla, S., et al. An Overview of the Beneficial Effects of Hydrolyzed Collagen as a Nutraceutical on Skin Properties: Scientific Background and Clinical Studies, The Open Nutraceuticals Journal 2015; 8(1):29-42.

Snedeker, J., Foolen, J. Tendon injury and repair—A perspective on the basic mechanisms of tendon disease and future clinical therapy. Acta Biomaterialia 2017; 63:18-36.

Svennsson,R., et al. Effect of aging and exercise on the tendon. Applied Physiology 2016; 121: 1353-1362.

Wessner, B., Liebensteiner, M., et al. Age-specific response of muscle extracellular matrix to acute resistance exercise: A pilot study. European Journal of Sports Science. Oct 2018.

Yazaki, Misato. Oral ingestion of collagen hydrolysate leads to the transportation of highly concentrated Gly-Pro-Hyp and its hydrolyzed form of Pro-Hyp into the bloodstream and skin. Journal of Agricultural and Food Chemistry 2017; 65:2315-2322.

Zabrzynski, J., et al. Tendon—Function related structure, simple healing process, and mysterious aging. Folia Morphologica. 2018; 77(3):416-427.

Zdzieblik, D., et al. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl. Physiol. Nutr. Metab. 2017.

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